Ben Te'o and James Haskell have been challenged to carry the impact they have made as replacements into the starting line-up when England face Italy on Sunday.
The RBS 6 Nations title defence continues with the visit of Conor O'Shea's Azzurri to Twickenham, with the Red Rose seeking a 17th consecutive win.
Te'o and Haskell made telling contributions to the late victories over France and Wales, arriving off the bench to unleash a succession of muscular carries at a time when England needed fresh momentum.
It will be rugby league convert Te'o's first start after winning all five of his caps as a replacement, and head coach Eddie Jones is eager to see how he performs at outside centre.
Haskell is restored to the back row having completed his recovery from toe surgery to make his first start since last summer's triumphant tour to Australia.
"Ben and James have had a real impact off the bench for us in this Six Nations," scrum coach Neal Hatley said.
"This is an exciting opportunity for them, particularly for Ben. We know what Haskell gives the team, so this is a chance to see what Ben can do.
"He's a strong runner and he's waited for the opportunity to start for some time now, so he's champing at the bit."
Source: PA
